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This page is intended for Healthcare Professionals and Persons Qualified to Prescribe or Supply.

Mereo is driven by a true understanding of the critical nature of our mission

At Mereo, we are working toward a future where people and families living with rare diseases, especially those with few or no treatment options, have access to therapies that can transform their lives.

We navigate the complexities of rare disease drug development to deliver therapies to the people who need them most. We do this in a capital-efficient manner. Central to our mission is working with patient organizations, physicians and healthcare systems so that we advance promising therapies for rare diseases.

Osteogenesis Imperfecta (OI)

Osteogenesis imperfecta (OI) is a serious, rare genetic disorder caused by a problem in the formation of type I collagen, and characterized by fragile bones that fracture easily, often starting from birth. It can affect people’s lives in a multitude of ways, from frequent fractures and skeletal deformities to constant chronic pain, respiratory insufficiency and hearing loss. And each person’s experience is different.

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OI community

Alpha-1 Antitrypsin Deficiency (AATD)

Alpha-1 Antitrypsin Deficiency (AATD) is a rare, genetic condition that results in a deficiency of alpha-1 antitrypsin, a protein that protects the lungs and liver against environmental damage, as well as against attack by neutrophil elastase, a key enzyme that the body releases during inflammation. Without this protein, or with defective proteins, inflammation has both acute and long-term effects.

People living with Alpha-1 Antitrypsin Deficiency-associated Lung Disease (AATD-LD) experience gradual, irreversible loss of lung function due to the permanent destruction of the lungs’ supportive elastic tissues.

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Making a difference for people living with rare diseases

We listen to physicians across the globe to understand their needs with regard to the rare conditions in which we work. We also ask people living with rare conditions what they would like their healthcare professionals to understand about their experiences. As a result, we create resources for healthcare professionals that provide the latest evidence-based understanding of the mechanism of a condition, the burden of disease, current practice, and unmet needs.

Access these resources below.

IMPACT Survey Publications

Project SATURN – a real-world evidence data collaboration with existing European datasets in Osteogenesis Imperfecta to support future therapies

SATURN: assessing the feasibility of utilising existing registries for real‑world evidence data collection to meet patients, regulatory, health technology assessment and payer requirements

Content validity of the St. George’s Respiratory Questionnaire – COPD (SGRQ-C) in Patients with Alpha-1 Antitrypsin Deficiency

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