We are currently completing a Phase 1a/b clinical trial in patients with advanced or metastatic solid tumors, in collaboration with Celgene Corporation. The Phase 1a portion investigated single agent activity with the Phase 1b in combination with nivolumab. Etigilimab is an anti-TIGIT therapeutic candidate designed to activate the immune system through multiple mechanisms and enable anti-tumor activity. TIGIT (T-cell immunoreceptor with Ig and ITIM domains) is an inhibitory receptor that is thought to prevent T-cells from attacking tumor cells, similar to the inhibitory protein PD-1.
Information on OncoMed's anti-TIGIT clinical program is available here: OMP-313M32 ClinicalTrials.gov. This program is part of OncoMed's collaboration with Celgene Corporation.
Public presentations of data from OncoMed's anti-TIGIT program include:
- Initial results from a phase 1a/b study of etigilimab (OMP-313M32), an anti-T cell immunoreceptor with Ig and ITIM domains (TIGIT) antibody, in advanced solid tumors -SITC 2018
- Anti-TIGIT biomarker study: Inhibition of TIGIT induces loss of T regs from tumors and requires effector function for tumor growth inhibition - AACR 2018
- Pharmacodynamic biomarkers for anti-TIGIT treatment and prevalence of TIGIT expression in multiple solid tumor types - AACR 2017
- Anti-TIGIT induces T cell-mediated anti-tumor immune responses and combines with immune checkpoint inhibitors to enhance strong and long term anti-tumor immunity-AACR 2017
- Antibody against T cell Immunoreceptor with Ig and ITIM domains (TIGIT) Induces anti-Tumor Immune Response and Generates Long-Term Immune Memory - AACR 2017