The following shareholders hold in excess of 3% or more of the Company’s issued share capital (PROFORMA):

Institutional Shareholder Number of Shares  % of Issued Share Capital
Link Fund Solutions Ltd 19,153,667 19.55%
Invesco Asset Management 19,149,176 19.55%
Novartis Pharma AG 15,703,871 16.03%
Woodford Investment Management Ltd 7,845, 873 8.00%
Primecap Management 3,480,550 3.55%

The Directors hold the following shareholding interest in the company: 

Directors  Number of Shares* % of Issued Share Capital
Kunal Kashyap 1,497,735 1.56%
Deepa Pakianathan** 1,283,670 1.34%
Denise Scots-Knight  929,699  0.88%
Peter Bains  206,796  0.22%
Anders Ekblom  139,702  0.15%
Peter Fellner 40,000 0.04%
Paul Blackburn 22,624 0.02%
Richard Jones  15,375  0.00%

* ordinary shares figures include ordinary shares represented by ADSs
** as a General Partner of Delphi Ventures

Issued share capital 97,959,622

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