The following shareholders hold in excess of 3% or more of the Company’s issued share capital (PROFORMA):

Institutional Shareholder Number of Shares  % of Issued Share Capital
Link Fund Solutions Ltd 19,031,915 15.29%
Invesco Asset Management 17,392,000 13.96%
Novartis Pharma AG 15,703,871 12.63%
Aspire Capital Fund LLC 14,295,520  11.50%
Boxer Capital, LLC 12,252,715 9.80%
Schroder UK Public Private Trust 7,845,873 6.3%

The Directors hold the following shareholding interest in the company: 

Directors  Number of Shares* % of Issued Share Capital
Kunal Kashyap 1,497,735 1.20%
Deepa Pakianathan** 1,283,670 1.03%
Denise Scots-Knight  929,699  0.75%
Peter Bains  206,796  0.17%
Anders Ekblom 189,702  0.15%
Richard Jones  66,915  0.05%
Peter Fellner 65,500 0.05%
Paul Blackburn 22,624 0.02%

* ordinary shares figures include ordinary shares represented by ADSs
** as a General Partner of Delphi Ventures

Issued share capital 124,507,857

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