The following shareholders hold in excess of 3% or more of the Company’s issued share capital (PROFORMA):

Institutional Shareholder Number of Shares  % of Issued Share Capital
Link Fund Solutions Ltd 19,153,667 17.06%
Invesco Asset Management  18,175,000 16.19%
Novartis Pharma AG 15,703,871 13.99%
Aspire Capital Fund LLC 14,295,520  12.73%
Schroder Investment Mgt (London) 7,845,873 8.01%
Primecap Mgt (Pasadena) 3,416,780 3.49%

The Directors hold the following shareholding interest in the company: 

Directors  Number of Shares* % of Issued Share Capital
Kunal Kashyap 1,497,735 1.33%
Deepa Pakianathan** 1,283,670 1.14%
Denise Scots-Knight  929,699  0.83%
Peter Bains  206,796  0.18%
Anders Ekblom 189,702  0.17%
Richard Jones  66,915  0.06%
Peter Fellner 65,500 0.06%
Paul Blackburn 22,624 0.02%

* ordinary shares figures include ordinary shares represented by ADSs
** as a General Partner of Delphi Ventures

Issued share capital 112,255,142

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