The following shareholders hold in excess of 3% or more of the Company’s issued share capital (PROFORMA):

Institutional Shareholder Number of Shares  % of Issued Share Capital
Woodford Investment Management 29,843,946 31.10%
Invesco Asset Management 19,149,176 19.90%
Novartis Pharma AG 13,767,841 14.30%
Canaccord Genuity Wealth Mgt 2,870,000 3.00%

The Directors hold the following shareholding interest in the company: 

Directors  Number of Shares % of Issued Share Capital
Kunal Kashyap 1,497,735 1.56%
Deepa Pakianathan* 1,283,670** 1.34%
Denise Scots-Knight 844,499 0.88%
Peter Bains   107,906 0.11%
Anders Ekblom 93,002 0.10%
Paul Blackburn 22,624 0.02%
Peter Fellner 10,000 0.01%

*as a General Partner of Delphi Ventures
**1,283,670 ordinary shares are held as ADSs

Issued share capital 96,023,592

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