The following shareholders hold in excess of 3% or more of the Company’s issued share capital:

Institutional Shareholder Number of Shares  % of Issued Share Capital
Woodford Investment Management 29,843,946 41.89%
Invesco Asset Management 19,149,176 26.88%
Novartis Pharma AG 13,767,841 19.33%
Hargreave Hale 2,870,000 4.03%

The Directors hold the following shareholding interest in the company: 

Directors  Number of Shares % of Issued Share Capital
Kunal Kashyap 1,497,735 2.10%
Denise Scots-Knight 844,499 1.19%
Frank Armstrong 256,444 0.36%
Peter Bains 108,206 0.15%
Anders Ekblom 93,002 0.13%
Paul Blackburn 22,624 0.03%
Peter Fellner 10,000 0.01%
Issued share capital 71,240,272

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